10 Standout Episodes from Grey’s Anatomy!

Grey’s Anatomy is the longest-running primetime medical drama in TV history and is ABC’s longest-running current show. Today, we bring you the 10 standout moments from the show that brought us so many emotions.

“The Sound of Silence” – Season 12, Episode 9

This episode has a 9.2/10 rating on IMBD with 2.2k reviews. Meredith Grey is attacked by a patient who is suffering from a neurological episode. They are left alone for a while before anyone realizes what had happened to her. She is left with damaged hearing, and her jaw is wired shut. She struggles with recovering, and when her children come to see her, they are horrified to see their mother’s appearance. This episode shows Meredith’s personality as a survivor.

Throughout the entire episode, fans experience Meredith’s struggle, seeing the world move around her without being able to have control. We all know Meredith as the survivor, but during the 43-minute episode, you can’t help but wonder what will happen next.

“Deterioration of the Fight or Flight Response” – Season 2, Episode 26

IMBD gave this episode a 9.0/10 rating with 1.8k reviews. Denny Duquette and Izzie Stevens are easily one of the best couples in Grey’s Anatomy history, which makes this episode even more painful to watch. The interns have cut Denny’s L-Vad wire in hopes to get him a heart transplant faster. Unfortunately, there are things they don’t know, and Denny ends up dying due to their intervening. The interns all take the blame together, even though Izzie was the one who came up with the idea and pushed the others to help, proving the amazing bond between the OG interns from the show.

This episode, like most, leaves fans on the edge of their seat, and as Denny quickly became a fan favorite, and it is vital for everyone to know if Izzie’s patient will be saved or if the interns will have a job the next day.

“My Shot” – Season 16, Episode 8

In the 350th episode, Meredith faces the Medical Board, where they are deciding if she can keep her medical license or not. While Meredith’s career hangs on the line, she finds out one of the doctors on the panel is Dr. Paul Castello, the man who we later come to find out is responsible for the death of our beloved McDreamy. An entire room full of Meredith Grey supporters appear in honor of the doctor who has changed so many lives; even Katie Bryce, Meredith’s first patient, comes back to make an appearance.

On IMBD, the episode has a 9.0/10 rating with 1.2k reviews. It is definitely one of those episodes you need to watch to have a feel good moment. This episode leaves fans crying not tears of sadness for a change but ones of joy.

“How to Save a Life” – Season 11, Episode 21

This is an episode we always have to prepare ourselves for. Derek Shepard is on his way to resigning from his dream job to support Meredith and his family. On the way, he witnesses a car crash and pulls over to save the victims; however, as he gets ready to depart from the crash site after saving the lives, he is later the victim. He doesn’t pass away because of the crash; it is due instead to the doctors overseeing possible head injuries not performing a C.T. scan. Derek is declared brain-dead, concluding the story of Dr. Shepard and the love story between Derek and Meredith.

Although one of the most important episodes to understand Meredith’s story, it is one of the least-rated shows from the series. Many fans felt as though this episode was one of the last they could watch due to many of their favorite characters being killed off.

“Flight” – Season 8, Episode 24

This episode begins with Meredith, Christina Yang, Derek, Mark Sloan, Lexie Grey, and Arizona Robbins dealing with the aftermath of a plane crash they were involved in. Arizona has a broken femur, Derek is lost, and Lexie is stuck under the remains of the plane. Back in Seattle’s Grace Mercy West Hospital, Owen Hunt has fired his best friend, Teddy Altman, for her to take advantage of the opportunity at Medcom. The episode has an 8.8/10 rating with over 2k reviews on IMBD.

This episode always has us in shambles, and fans feel the same way. From losing fan favorites, Lexie Grey and Mark Sloan, this is definitely a tough one to watch.

“Fear (of the Unknown)” – Season 10, Episode 24

In this episode, we see the end of a chapter of the friendship between Meredith and Christina. There is an explosion at a mall which allows Christina to find a valid excuse to not leave the hospital, but instead, it turns out that this is what she needed to have closure; one last moment to dance it out with her BFF, Meredith. She leaves to become the Director of Cardiothoracic Surgery in a hospital in Zurich, Switzerland.

This episode was given a 9.2/10 rating on IMBD with 1.8k reviews. We see one of the OG characters depart, and fans were heartbroken to see such an iconic character and friendship end.

“Now or Never” Season 5, Episode 24

This was one of the most heart-wrenching episodes for many reasons. Meredith and Derek had written their Post-It note vows, Izzie begins losing her memory after her brain surgery for her cancer, and to top it all off, fan-favorite George O’Malley reveals himself as the John Doe who saved a woman from being hit by a bus and is now in critical condition. Fans are left on the edge of their seats, with the episode ending with both Izzie and George flatlining.

On IMBD, the episode has a 9.5/10 rating with 2.8k reviews. Fans took to social media to share their upsets with the show killing George as well as to share the emotions they felt watching the episode.

 “Silent All These Years” – Season 15, Episode 19

Looper.com ranks this episode second on their list. The episode is about a patient who comes in after she was sexually assaulted at the bar, and ends up growing very close to Jo Wilson. The spine-chilling moment happens when Dr. Wilson comes up with the plan of having the women of Grey Sloan Memorial Hospital line up the hallway to show support as the patient is getting ready to go into the operating room.

Many fans agree that this emotional episode faces important topics that must be discussed. Many say it is one of the most powerful episodes the show has ever produced. On IMBD, the episode has a 9.5/10 rating with over 2.7k reviews.

“Death and All His Friends” – Season 6, Episode 24

This episode was given a 9.7/10 rating with over 3.7k reviews on IMBD. This and the episode before it, “Sanctuary,” are one of highest rated episodes from the series. A gunman in the hospital is ready to get revenge on Derek Shepard for pulling the plug on his wife. The episode continues to leave fans on the edge of their seats, hoping that their favorite characters will survive to see the next season.

For many fans, this episode was a hard one to watch, and TV Fanatic says that the “writing and acting were absolutely stellar….” The episode gave each character their moment to shine and allowed us to mourn those lost in the episode. Although an episode that brings tears to many who watch, fans cannot stop.

“It’s the End of the World” – Season 2, Episode 16

Finally, in 1st place, we have “It’s the End of the World” with over 37.88 million viewers, making it Grey’s Anatomy’s most viewed episode of all time. The episode begins with a man arriving at the hospital who has live ammo inside of him, and the only thing keeping him alive are the hands of a paramedic named Hannah.

This episode received a lot of love and compliments from Grey’s fanbase. Ellen Pompeo is still blown away by it, and fans were left with so many emotions, from anxiety, fear, and sadness… let’s just say the episode was a lot. On IMBD, the episode has a 9.4/10 rating with over 2.9k reviews on the site.

About the Author

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Izzy Oropeza

Izzy Oropeza is a Junior at Penn State University majoring in advertising/public relations with a minor in theatre. She is an intern for AfterBuzzTV and Heal Squad with Maria Menounos and she hopes to pursue a career in the entertainment industry, whether on the screen or behind the scenes.